Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS): Evidence map

This project is now completed and published.

The published paper can be accessed within the NIHR Journals Library:

Recent research in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome: an evidence map 

Or as a PDF document:

The interactive evidence map can be accessed here:

Evidence map of national and international research in ME/CSF 

The protocol is published on Open Science Framework:

ME/CFS: an evidence map of research studies and how these address key themes in the JLA PSP research priorities (Protocol)

Research summary:

Why is this research important?
Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a chronic condition affecting approximately 17 million people globally. It is characterized by persistent fatigue, post-exertional malaise (symptoms worsen after exertion), and various other symptoms.

What did we do?
We created an interactive evidence map of ME/CFS research published between 2018 and 2023, summarising the volume and key characteristics of studies in this area. This involved a comprehensive literature search and the inclusion of relevant studies based on defined criteria. We categorized data, assessed the methodological quality of systematic reviews using AMSTAR2, and aligned this research with the priorities set by the James Lind Alliance Priority Setting Partnership (JLAPSP).

What did we find?
Out of 11,278 studies searched, 639 met our criteria and included data on roughly 610,000 people with ME/CFS. The majority of studies came from high-income countries, but participant demographic reporting was often inadequate. The evidence map revealed that 53% of studies addressed the causes of ME/CFS, while fewer focused on the problems associated diagnosis, assessment and potential interventions. Our findings were used to guide the ME/CSF Research Working Group delivery plan, underpinning actions to build capacity and capability for research into ME/CFS.

Knowledge mobilisation and dissemination activities:

The findings contributed to a recent Government policy paper which aims to improve care and support for people with ME/CFS which was published in July 2025.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): the final delivery plan

We also presented our findings at the JBI European Symposium in Aberdeen, May 2026.