This video is intended to help general practitioners, and hospital and palliative care specialists to make advance care planning tailored to the course of progressive illness and the person’s wishes. This short video offers an overview of illness trajectories relevant to people with any progressive illness(s), and suggests how they can be incorporated into a four-stage care cycle for advance care planning. Particular attention is given to consider how patients with two or more significant illnesses can receive person-centred and coordinated care. Key Points Most patients with progressive illness follow characteristic trajectories of decline, previously identified as rapid, intermittent, or a gradual decline from a low baselineMultimorbidity is increasingly common and follows a distinct fourth trajectoryAn understanding of the dynamic multidimensional trajectories of patients with progressive illnesses helps clinicians consider individual holistic needs and have meaningful conversations with patients and families about advance care planningIn patients with an acute deterioration in health (such as from an infection), considering the main underlying illness trajectory helps guide shared decision making about realistic current and future treatment and care optionsThe video was embedded into the online abstract of a paper submitted to the BMJ. Click to access the paper and embedded video Citation Murray SA, Boyd K, Moine S, Kendall M, Macpherson S, Mitchell G, Amblàs-Novellas J. Using illness trajectories to inform person centred, advance care planning. BMJ 2024; 384 :e067896 doi:10.1136/bmj-2021-067896 This article was published on 2025-01-23