Manu's research programme aims to enable precision immunomodulation in critically ill adults with sepsis and acute respiratory distress syndrome (ARDS). Manu's core hypothesis is that modifiable biological networks generate clinical phenotypes and such networks could be determined by integration of clinical and immunobiology data. Professor Manu Shankar-Hari Chair of Translational Critical Care Medicine / Honorary Consultant in Intensive Care Medicine Contact details Phone: S.Keggie@ed.ac.uk Website: TRAITS Programme Background I will be starting as Chair of Translational Critical Care Medicine at CIR in February 2022, moving up to Edinburgh from King's College London. I am a clinician scientist. I trained in Intensive Care Medicine in London. My research training included MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, and PhD in lymphocyte biology at the Peter Gorer Department of Immunobiology at King’s College London, UK. My research programme aims to enable precision immunomodulation in critically ill adults. The immunobiology focus of my lab is to identify modifiable biological networks within the phenotypic and molecular changes in lymphocytes during critical illness and enduring changes following recovery from critical illness. Research Overview Critical illness is a major cause of morbidity and mortality globally. Even for the two most common critical illness syndromes - sepsis and acute respiratory distress syndrome (ARDS) - there are no effective treatments other than supportive care. My lab pursues the hypothesis that critical illnesses reflect perturbations within intracellular and intercellular networks that link cells, and organ systems. Illness networks arise from functional interdependencies between the molecular components within human cells. Many of these illness networks are causal and determine clinical phenotypes. Thus, my lab's two focussed research themes of immunobiology and epidemiology converge to a core aim of determining these observable and treatable immunological abnormalities in critical illness (treatable traits). The immunobiology focus of my lab are the phenotypic and molecular changes in T and B lymphocytes during critical illness and resolution from critical illness, to determine modifiable changes that could improve patient outcomes. This information is used to design seamless early to late phase human randomised clinical trials to translate immune changes into treatments for patients. Biographical Profile Manu Shankar-Hari trained in Intensive Care Medicine in London, completed MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, and did his PhD in Immunology at the Peter Gorer Department of Immunobiology at King's College London, UK. Manu was appointed as a consultant physician in Intensive Care Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust in 2009. He was awarded the NIHR Clinician Scientist Fellowship in 2016 to investigate the long-term health consequences of sepsis survivors and to undertake a clinical trial of vaccinating to reduce long-term health care burden in adult sepsis survivors. Manu was appointed to the Chair of Translation Critical Care Medicine at the University of Edinburgh in 2022. Honours and Awards 2019 - Lowry Fink Fellowship, International Sepsis Forum 2017 - Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society 2016 - NIHR Clinician Scientist Fellowship 2002 - Sanjeevani Gold Medal for best MD Student, All India Institute of Medical Sciences 2001 - TJ Memorial Award for best MD Thesis, Indian Society of Anaesthesia 1997 - Awarded for Best Undergraduate Student in Medicine, Trivandrum Medical College, India Alumni Dr Michael Carter, NIHR ACL (Moving to be Physicien Hospitalier, Pediatric Intensive Care, Bicetre Hospital, AP-HP Paris-Saclay University, Paris, France) Dr Silvia Cellone-Trevelin, Postdoctoral Research Associate Dr Yasmeen Ghnewa, Postdoctoral Research Associate Dr Liang Ma, Postdoctoral Research Associate Ms Carolyn Lam, Research Assistant Ms Vera Peters, PhD Student Other Responsibilities Board Member, EME Funding Committee Director of Research, UK Intensive Care Society Associate Editor, Intensive Care Medicine UK Representative, European Society of Intensive Care Medicine Collaborators Internal Professor Adriano Rossi, University of Edinburgh Professor Kev Dhaliwal, University of Edinburgh Dr Sohan Seth, University of Edinburgh External ICNARC Professor Jo Spencer Dr Chad Swanson HTML Funding Manu's group is funded primarily by grants from the NIHR; NIHR HTA programme; MRC-EME programme; MRC; National Institute of Academic Anaesthesia; HDR UK; UKRI COVID-19 Funding Sources of funding held in CIR : NIHR HTA programme MRC-EME programme HDR UK This article was published on 2024-09-24
