The main aim of this study is to establish if giving regular, low dose morphine capsules twice a day are better than placebo (dummy) for chronic breathlessness and whether morphine improves daily activity. A parallel group, double-blind, randomised, placebo-controlled trial comparing the effectiveness and cost effectiveness of low dose oral modified release morphine versus placebo on patient-reported worst breathlessness in people with chronic breathlessness. Chief Investigator: Miriam Johnston Number and location of participating sites (by region/ country): Multiple sites across the UK ISRCTN87329095 EudraCT number: 2019-002479-33 Funder: HTA Start and End date: Of grant award March 2019 to August 2022 Of recruitment April 2020 - Current Status: Recruitment starting April 2020 Trial Unblinding Information: In circumstances where unblinding is necessary please refer to the protocol and follow instructions provided. Contact details are provided below. Contact details: Sponsor: Hull University Teaching Hospitals NHS Trust (UK) Professor Miriam Johnson miriam.johnson@hyms.ac.uk Bronwen Williams 01482 462271 bronwen.williams@hyms.ac.uk Research Nurse: N/A ECTU involvement: Statistics and Health Economics Image This article was published on 2024-09-24
