MND-SMART: Motor Neurone Disease Systematic Multi-Arm Adaptive Randomised Trial The aim of this clinical trial, called MND-SMART, is to improve outcomes for people living with MND. We plan to evaluate numerous repurposed medicines over many years using a multi-arm multi-stage trial design. Multi-arm means more than one drug is tested at one time. ‘Repurposing’ is investigating if a drug that has already been approved to treat one disease may be beneficial in treating another. The trial will be conducted in four stages and only continue if the results of each stage meet pre-defined criteria. In stages 1-3 the outcome measure ALS-FRS(R), a functional scale used in MND, will be evaluated alongside the safety and tolerability of the drugs. In stage 4 we will analyse the effects of drugs on survival. The latest information on trial status and investigational treatments is available from the MND-SMART website www.mnd-smart.org Chief Investigator: Prof Siddharthan Chandran Image Number and location of participating sites / geographical scope (by region/country): UK 12 sites EudraCT Number: 2019-000099-41ISRCTN number: NCT04302870 https://www.clinicaltrials.gov/ct2/show/NCT04302870Funder: MND Scotland, Alan Davidson Foundation, My Name'5 Doddie Foundation, Motor Neurone Disease Association and Baillie Gifford Start and End dateOf grant award: 01 November 2018 - 31 October 2028Of recruitment: October 2028 Current status: Currently recruiting Website: https://www.mnd-smart.org/ Participant Area: https://www.mnd-smart.org/about/participant-information Trial Unblinding Information: The PI, or delegate with authority to unblind, will log-in to the trial database using their username and password Sponsor: ACCORDChief Investigator: Prof Siddharthan Chandran, Centre for Clinical Brain Sciences, 49 Little France Crescent, Edinburgh, EH16 4SB UK GDPR Privacy Statement: Document MND-SMART DATA PROTECTION INFORMATION SHEET V1.0 (196.46 KB / 0) ECTU Involvement: Statistics / Data Management This article was published on 2024-09-24