For patients <60 years with moderate-severe medial compartment osteoarthritis (OA), there is uncertainty regarding the most effective treatment (surgical management with HTO or non-surgical management with structured physiotherapy), as arthroplasty in these patients is associated with a comparatively poor outcome. This trial will compare the clinical and cost-effectiveness of HTO with structured Personalised Knee Therapy (PKT) in patients <60 years with symptomatic medial compartment knee OA. What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with non-surgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 50 years? (MOTION Trial) Image Chief Investigator: Mr Anish Amin Number and location of participating sites (by region/ country): UK 20 sites EudraCT number: N/A ISRCTN number: ISRCTN99042491 Funder: NIHR Start and End date Of grant award: 01 August 2022 to 31 July 2027 Of recruitment: 28 February 2023 to 31 January 2025 Current Status: Currently recruiting Trial Website: N/A Email: MOTION.Trial@ed.ac.uk UK GDPR Privacy Statement: Information can be found in our Patient Information Sheet. Patient Information Sheet: Document MOTION PISCF_Appendix 1_v4.0_10Oct2023 (390.63 KB / 0_10OCT2023) You can find out more about how we use your information • At www.hra.nhs.uk/information-about-patients/ • Our leaflet available from www.hra.nhs.uk/patientdataandresearch • By asking one of the research team • By sending an email to motion.trial@ed.ac.uk • By contacting a Data Protection Officer University of Edinburgh Data Protection Officer Governance and Strategic Planning University of Edinburgh Old College Edinburgh EH8 9YL Tel: 0131 651 4114 dpo@ed.ac.uk NHS Lothian Data Protection Officer NHS Lothian Waverley Gate 2-4 Waterloo Place Edinburgh EH1 3EG Tel: 0131 465 5444 Lothian.DPO@nhs.net Co-sponsor Representative: http://accord.scot/ Chief Investigator Mr Anish Amin, Consultant Trauma and Orthopaedic Surgeon, Royal Infirmary Edinburgh, Orthopaedics, 51 Little France Crescent, Edinburgh, EH16 4TJ; Anish.K.Amin@ed.ac.uk Trial Manager: Rachel Locherty Assistant Trial Manager: Hannah Rickman Email: MOTION.Trial@ed.ac.uk For more information, the protocol and list of participating sites, please visit: ISRCTN registry ECTU involvement: Trial management / Statistics / Health Economics/ Database / Randomisation service. (UKCRC) This article was published on 2024-09-24
