PIPIN

Preterm birth contributes to around 11% of all births worldwide and is the major cause of infant morbidity and mortality. Whilst in the UK survival of babies born preterm has improved, the proportion of survivors without long term developmental problems has not, and current treatments are ineffective at preventing this. This study aims to see whether women in preterm labour would be willing to be randomised to take a tablet (pravastatin) or placebo. Preterm labour is known to be due to both inflammation within the womb and contractions. Pravastatin in an anti-inflammatory agent which has been used safely in pregnancy, and which appears in in animal studies to reduce preterm labour associated events.

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We hope if women are willing to accept this trial and participate, this will help us develop a larger clinical study to find a new treatment for preterm labour.

Chief Investigator: Professor Jane Norman

Number and location of participating sites / geographical scope (by region/ country): UK Single Site; aim to include second UK site in January 2019

EudraCT number: 2017-005021-21

Funder: CSO

Start and End date

Of grant award August 2018 – July 2020

Of recruitment

Status: Currently recruiting

 If you have participated in this study and would like to read how the study complies with UK GDPR, please click on this link:

Website: https://www.ed.ac.uk/centre-reproductive-health/clinical-studies

Sponsor: ACCORD http://accord.scot/

Chief Investigator: Professor Jane Norman, QMRI; jane.norman@ed.ac.uk

Trial Manager: Sonia Whyte

Clinical Research Fellow: Dr Eleanor Whitaker; eleanor.whitaker@ed.ac.uk 0131 2426613

ECTU involvement: Statistics, database and randomisation service