A Phase II study of 3 fractions of Prostate SBRT with RayPilot system & HypoCath image guidance for men with NCCN low or intermediate risk prostate cancer The Precision study will investigate whether it is possible to reduce the number of curative radiotherapy doses from 5 to 3. We will use a system called RayPilot HypoCath to continuously track the prostate position during the radiotherapy, so that the same treatment can be delivered over a 3-dose schedule. The study will look at whether the side effects are the same over the 3-dose schedule as the 5-dose schedule. Chief Investigator: Prof Duncan McLaren Number and location of participating sites (by region/ country): up to 10 UK sitesEudraCT number: N/AISRCTN number: N/A Clincaltrials.gov ref: NCT06117059 Funder: Jamie - King Urological Cancers Research Fund Start and End dateOf grant award: from 01 May 2026Of recruitment: from 01 Feb 2025 Current Status: Currently recruiting Trial Website: UK GDPR Privacy Statement: Within patient information sheet Sponsor: ACCORD http://www.accord.ed.ac.uk/Chief Investigator: Professor Duncan McLaren, Consultant Oncologist, Edinburgh Cancer Centre, Western General Hospital, Edinburgh, EH4 2LF Email: Duncan.McLaren@ed.ac.ukTrial Manager: Edinburgh Clinical Trials Unit, Usher Building, The University of Edinburgh, 5‒7 Little France Road, Edinburgh BioQuarter ‒ Gate 3 EDINBURGH EH16 4UX Email:precision.study@ed.ac.uk ECTU involvement: Trial Management / Statistics / Data Management This article was published on Tuesday 3 November 2026