At-Risk Registers Integrated into primary care to Stop Asthma crises in the UK ARRISA-UK is a randomised controlled trial of GP practice staff training and high risk patient identification and flagging to reduce the occurrence of severe asthma related events.Preventable hospital admissionsUnfortunately, far too many patients with asthma are admitted to hospital (approximately 72,000) or die (approximately 1150) unnecessarily in the UK every year.We have excellent drugs available for asthma and clear advice on prescribing them that should allow asthma to be controlled in most patients.It is known that certain asthma patients are at greater risk of being admitted or dying than others and that targeting intensive support and care to these patients improves their health.Flagging people at risk – and learning how to helpWe have undertaken a study that identified ‘at-risk’ patients within GP practices and used computer-based systems to create pop-up alerts when these patients contact the practice. Practice staff were trained on what to do when they see the alert.This didn’t reduce the total number of attacks but reduced the hospital admissions as more patients appeared to receive appropriate treatment for their asthma.Based on these promising findings we wish to undertake a nationwide study to confirm that we can improve the care of these patients without costing the NHS too much or affecting the care of other asthma patients within GP practices.What are we doing about it?We will identify patients who are at risk of having severe asthma attacks from GP practices in six regions within the UK, by searching their practice records for factors that predict risk of attacks.In half of the GP practices, a pop-up alert will appear on the computerised medical notes whenever any of the ‘at-risk’ patients make contact with anyone in the practice. This alert will, for example, remind receptionists to book urgent appointments, GPs and nurses to advise patients to take their medication and follow their written asthma action plans and pharmacists to ensure patients take their medicines.All practice staff will receive training on how to respond to the alerts, supported by web-based resources and practice study champions, with reminders at 6 weeks and 6 months.We will use data available routinely from the GP practice and will not need to collect information directly from patients for our study.After 12 months, we will count how many patients attended Accident and Emergency, had a hospital admission, or died due to asthma in each group.We will also find out how many people have well controlled asthma, what medications are prescribed for asthma, how often patients attend routine appointments and if they stop smoking.We will calculate how much this costs and whether it improves (or interferes with) the care of other patients with asthma in the practice.We will work out which patients gain the most from our study. With their permission, we will arrange focus groups and interview for patients and staff, to discuss their thoughts about the at-risk registers and the training and how it worked in practice. Key People Andrew WilsonLead: Preventing asthma attacksBased at: University of East AngliaAndrew's Profile Gary BartonProfessor of Health EconomicsBased at: University of East AngliaGary's Profile Christopher ButlerCo-applicantBased at: Cardiff University Ann CaressCo-applicantBased at: University of HuddersfieldAnn's Profile Allan ClarkSenior Lecturer in Medical StatisticsBased at: University of East AngliaAllan's Profile Chris GriffithsCentre DirectorLead: Preventing asthma attacksBased at: Queen Mary University LondonChris' Profile Stan MusgraveResearch FellowBased at: University of East AngliaStan's Profile Mike NobleGeneral PractitionerAcle Medical Partnership Helen PainterPublic and Patient Involvement Representative Hilary PinnockLead: Optimising management of asthma attacks,Lead: Postgraduate Training, Network CoordinatorBased at: University of EdinburghHilary's Profile David PriceProfessor of Primary Care Respiratory MedicineBased at: University of AberdeenDavid's Profile Aziz SheikhCentre DirectorBased at: University of EdinburghAziz's Profile Jane SmithSenior Lecturer in Primary CareBased at: University of ExeterJane's Profile Ann-Marie SwartProfessor of EpidemiologyDirector of the Norwich Clinical Trials UnitBased at: University of East AngliaAnn-Marie's Profile Mike ThomasProfessor of Primary Care ResearchBased at: University of SouthamptonMike's Profile Samantha WalkerDeputy Chief Executive of Asthma UK TimelineDec 2014 – October 2021Contact usARRISA-UK study team Clinical Trials Unit Norwich Medical School University Of East Anglia Norwich, NR4 7TJ01603 593 309ARRISA-UK.Med@uea.ac.ukTrial RegistrationThe ARRISA-UK study is registered with Controlled Clinical Trials: ISRCTN95472706The ARRISA-UK study is also registered on the UK Clinical Research Network: Study ID=18118.FundingNHS' National Institute for Health Research's Health Technology Assessment Programme (NIHR HTA) This article was published on 2024-09-24