Project: ARRISA-UK

At-Risk Registers Integrated into primary care to Stop Asthma crises in the UK

ARRISA-UK is a randomised controlled trial of GP practice staff training and high risk patient identification and flagging to reduce the occurrence of severe asthma related events.

Preventable hospital admissions

Unfortunately, far too many patients with asthma are admitted to hospital (approximately 72,000) or die (approximately 1150) unnecessarily in the UK every year.

We have excellent drugs available for asthma and clear advice on prescribing them that should allow asthma to be controlled in most patients.

It is known that certain asthma patients are at greater risk of being admitted or dying than others and that targeting intensive support and care to these patients improves their health.

Flagging people at risk – and learning how to help

We have undertaken a study that identified ‘at-risk’ patients within GP practices and used computer-based systems to create pop-up alerts when these patients contact the practice. Practice staff were trained on what to do when they see the alert.

This didn’t reduce the total number of attacks but reduced the hospital admissions as more patients appeared to receive appropriate treatment for their asthma.

Based on these promising findings we wish to undertake a nationwide study to confirm that we can improve the care of these patients without costing the NHS too much or affecting the care of other asthma patients within GP practices.

What are we doing about it?

We will identify patients who are at risk of having severe asthma attacks from GP practices in six regions within the UK, by searching their practice records for factors that predict risk of attacks.

In half of the GP practices, a pop-up alert will appear on the computerised medical notes whenever any of the ‘at-risk’ patients make contact with anyone in the practice. This alert will, for example, remind receptionists to book urgent appointments, GPs and nurses to advise patients to take their medication and follow their written asthma action plans and pharmacists to ensure patients take their medicines.

All practice staff will receive training on how to respond to the alerts, supported by web-based resources and practice study champions, with reminders at 6 weeks and 6 months.

We will use data available routinely from the GP practice and will not need to collect information directly from patients for our study.

After 12 months, we will count how many patients attended Accident and Emergency, had a hospital admission, or died due to asthma in each group.

We will also find out how many people have well controlled asthma, what medications are prescribed for asthma, how often patients attend routine appointments and if they stop smoking.

We will calculate how much this costs and whether it improves (or interferes with) the care of other patients with asthma in the practice.

We will work out which patients gain the most from our study. With their permission, we will arrange focus groups and interview for patients and staff, to discuss their thoughts about the at-risk registers and the training and how it worked in practice. 

Key People


Headshot of Andrew Wilson

Andrew Wilson

Lead: Preventing asthma attacks
Based at: University of East Anglia
Andrew's Profile

Headshot of Gary Barton

Gary Barton

Professor of Health Economics
Based at: University of East Anglia
Gary's Profile

Chris Butler

Christopher Butler

Co-applicant
Based at: Cardiff University

Headshot of Ann Caress

Ann Caress

Co-applicant
Based at: University of Huddersfield
Ann's Profile

Allan Clark

Allan Clark

Senior Lecturer in Medical Statistics
Based at: University of East Anglia
Allan's Profile

Chris Griffiths

Chris Griffiths

Centre Director

Lead: Preventing asthma attacks

Based at: Queen Mary University London
Chris' Profile

Stan Musgrave

Stan Musgrave

Research Fellow
Based at: University of East Anglia
Stan's Profile

Mike Noble

General Practitioner
Acle Medical Partnership

Helen Paynter

Helen Painter

Public and Patient Involvement Representative

headshot of Hilary Pinnock

Hilary Pinnock

Lead: Optimising management of asthma attacks,

Lead: Postgraduate Training, Network Coordinator

Based at: University of Edinburgh
Hilary's Profile

David Price

David Price

Professor of Primary Care Respiratory Medicine
Based at: University of Aberdeen
David's Profile

Headshot of Aziz Sheikh

Aziz Sheikh

Centre Director
Based at: University of Edinburgh
Aziz's Profile

Headshot of Jane Smith

Jane Smith

Senior Lecturer in Primary Care
Based at: University of Exeter
Jane's Profile

Headshot of Ann-Marie Swart

Ann-Marie Swart

Professor of Epidemiology

Director of the Norwich Clinical Trials Unit

Based at: University of East Anglia
Ann-Marie's Profile

Professor Mike Thomas

Mike Thomas

Professor of Primary Care Research
Based at: University of Southampton
Mike's Profile

Samantha Walker

Deputy Chief Executive of Asthma UK

Timeline

Dec 2014 – October 2021

Contact us

ARRISA-UK study team Clinical Trials Unit Norwich Medical School University Of East Anglia Norwich, NR4 7TJ

01603 593 309

ARRISA-UK.Med@uea.ac.uk

Trial Registration

The ARRISA-UK study is registered with Controlled Clinical Trials: ISRCTN95472706

The ARRISA-UK study is also registered on the UK Clinical Research Network: Study ID=18118.

Funding

NHS' National Institute for Health Research's Health Technology Assessment Programme (NIHR HTA)