This project works to use UK-wide data to study the uptake, safety and effectiveness of COVID-19 vaccines. The project was awarded through a funding call by Health Data Research UK and the Alan Turing Institute, and is led by Professor Aziz Sheikh. HTML Image Summary (Research in a nutshell)There are many questions that need to be answered about the safety and effectiveness of COVID-19 vaccines.Building on our earlier work, we engaged with a range of patient, public, community, professional and health policy groups who told us the following questions are the most important to them:‘What is the uptake, safety and effectiveness of COVID-19 vaccines’: for the following groups:in pregnancyin children and young peoplewhen given as booster doseson disease caused by different variants?'We will research the answers to the questions. The research will use linked datasets from across the UK. These will include general practitioner, vaccination, testing, viral sequencing, hospitalisation and death data. Trained, approved data analysts will have access to the data in secure and safe settings. This means people can be confident that health data is being accessed securely and privacy protected.We will be able to replicate findings in different national data sources and pool results on up to 55 million people across the UK.This work is beneficial to the public. Our patient and public involvement work has shown the importance of these questions. Our work will help to increase the confidence of the public in the COVID-19 vaccines.We will continue to work with the UK’s Chief Medical Officers, Chief Scientific Advisers, and government and vaccine bodies—in particular, the Joint Committee on Vaccination and Immunisation, and the Medicines and Healthcare products Regulatory Agency—so they are aware of our work and they will be ready to use our results to inform national decisions that benefit the public.Read more on the DaC-VaP-2 research siteKey peopleNameRoleAffiliationAziz SheikhSenior InvestigatorUniversity of Edinburgh / BREATHE - Health Data Research Hub for Respiratory Health / EAVE IISimon de LusignanSenior Investigator - EnglandUniversity of Oxford / Royal College of General Practitioners Research Surveillance CentreRichard HobbsSenior Investigator - EnglandUniversity of OxfordJenni QuintSenior Investigator - EnglandImperial College London / BREATHE - Health Data Research Hub for Respiratory HealthVahe NafilyanSenior Investigator - EnglandOffice for National StatisticsMark JoyCore researcher - EnglandUniversity of OxfordChris RobertsonSenior Investigator - ScotlandUniversity of Strathclyde / PHS / EAVE IISteven KerrCore researcher - ScotlandUniversity of EdinburghDeclan BradleySenior Investigator - Northern IrelandQueen’s University Belfast / Public Health AgencyDermot O’ReillySenior Investigator - Northern IrelandQueen’s University BelfastSiobhan MurphyCore researcher - Northern IrelandQueen’s University BelfastRonan LyonsSenior Investigator - WalesSwansea University / SAIL DatabankAshley AkbariSenior Investigator - WalesSwansea University / SAIL DatabankStuart BedstonCore researcher - WalesSwansea UniversityAntony ChuterPatient and Public Involvement Lead Jillian BeggsPatient and Public Involvement Lead Tracy JacksonPatient and Public Involvement Research FellowUniversity of EdinburghSusan BuckinghamCommunications and Engagement ManagerUniversity of EdinburghDominique BalharryResearch ManagerUniversity of EdinburghMorag EdwardsResearch AdministratorUniversity of EdinburghKey publicationsThis project builds on the first DaC-VaP project which ran from January to October 2021. The DaC-VaP team have contributed to publications that have informed the UK and Scottish Government responses to the pandemic, as well as our understanding of the effectiveness of COVID-19 vaccines.Read more about the original DaC-VaP studyTimelineNovember 2021 – September 2022Key CollaborationsBREATHE - Health Data Research Hub for Respiratory HealthEAVE II - Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 studyHealth Data Research UKImperial College LondonOffice for National StatisticsQueen's University BelfastRoyal College of General Practitioners Research Surveillance CentreSwansea UniversitySAIL DatabankUniversity of OxfordUniversity of StrathclydePartners and FundersThis project is part of the Data and Connectivity National Core Study - working to make vital data available to accelerate research on COVID-19. Data and Connectivity is led by Health Data Research UK, in partnership with the Office for National Statistics, funded by UK Research and Innovation and delivered alongside a UK-wde network of delivery partners. This work was also supported by The Alan Turing Institute via 'Towards Turing 2.0' EPSRC Grant Funding. Image WebsiteProject summary on the Health Data Research UK websiteContactPress and PRThe University of EdinburghTel: +44 (0)7979 446 209Email: press.office@ed.ac.uk All other enquiriesProject manager: Dominique Balharry, University of Edinburghd.balharry@ed.ac.uk Scientific themesCOVID-19, Vaccine Pharmacovigilance, Pregnancy, Boosters, Variants This article was published on 2024-09-24
HTML Image Summary (Research in a nutshell)There are many questions that need to be answered about the safety and effectiveness of COVID-19 vaccines.Building on our earlier work, we engaged with a range of patient, public, community, professional and health policy groups who told us the following questions are the most important to them:‘What is the uptake, safety and effectiveness of COVID-19 vaccines’: for the following groups:in pregnancyin children and young peoplewhen given as booster doseson disease caused by different variants?'We will research the answers to the questions. The research will use linked datasets from across the UK. These will include general practitioner, vaccination, testing, viral sequencing, hospitalisation and death data. Trained, approved data analysts will have access to the data in secure and safe settings. This means people can be confident that health data is being accessed securely and privacy protected.We will be able to replicate findings in different national data sources and pool results on up to 55 million people across the UK.This work is beneficial to the public. Our patient and public involvement work has shown the importance of these questions. Our work will help to increase the confidence of the public in the COVID-19 vaccines.We will continue to work with the UK’s Chief Medical Officers, Chief Scientific Advisers, and government and vaccine bodies—in particular, the Joint Committee on Vaccination and Immunisation, and the Medicines and Healthcare products Regulatory Agency—so they are aware of our work and they will be ready to use our results to inform national decisions that benefit the public.Read more on the DaC-VaP-2 research siteKey peopleNameRoleAffiliationAziz SheikhSenior InvestigatorUniversity of Edinburgh / BREATHE - Health Data Research Hub for Respiratory Health / EAVE IISimon de LusignanSenior Investigator - EnglandUniversity of Oxford / Royal College of General Practitioners Research Surveillance CentreRichard HobbsSenior Investigator - EnglandUniversity of OxfordJenni QuintSenior Investigator - EnglandImperial College London / BREATHE - Health Data Research Hub for Respiratory HealthVahe NafilyanSenior Investigator - EnglandOffice for National StatisticsMark JoyCore researcher - EnglandUniversity of OxfordChris RobertsonSenior Investigator - ScotlandUniversity of Strathclyde / PHS / EAVE IISteven KerrCore researcher - ScotlandUniversity of EdinburghDeclan BradleySenior Investigator - Northern IrelandQueen’s University Belfast / Public Health AgencyDermot O’ReillySenior Investigator - Northern IrelandQueen’s University BelfastSiobhan MurphyCore researcher - Northern IrelandQueen’s University BelfastRonan LyonsSenior Investigator - WalesSwansea University / SAIL DatabankAshley AkbariSenior Investigator - WalesSwansea University / SAIL DatabankStuart BedstonCore researcher - WalesSwansea UniversityAntony ChuterPatient and Public Involvement Lead Jillian BeggsPatient and Public Involvement Lead Tracy JacksonPatient and Public Involvement Research FellowUniversity of EdinburghSusan BuckinghamCommunications and Engagement ManagerUniversity of EdinburghDominique BalharryResearch ManagerUniversity of EdinburghMorag EdwardsResearch AdministratorUniversity of EdinburghKey publicationsThis project builds on the first DaC-VaP project which ran from January to October 2021. The DaC-VaP team have contributed to publications that have informed the UK and Scottish Government responses to the pandemic, as well as our understanding of the effectiveness of COVID-19 vaccines.Read more about the original DaC-VaP studyTimelineNovember 2021 – September 2022Key CollaborationsBREATHE - Health Data Research Hub for Respiratory HealthEAVE II - Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 studyHealth Data Research UKImperial College LondonOffice for National StatisticsQueen's University BelfastRoyal College of General Practitioners Research Surveillance CentreSwansea UniversitySAIL DatabankUniversity of OxfordUniversity of StrathclydePartners and FundersThis project is part of the Data and Connectivity National Core Study - working to make vital data available to accelerate research on COVID-19. Data and Connectivity is led by Health Data Research UK, in partnership with the Office for National Statistics, funded by UK Research and Innovation and delivered alongside a UK-wde network of delivery partners. This work was also supported by The Alan Turing Institute via 'Towards Turing 2.0' EPSRC Grant Funding. Image WebsiteProject summary on the Health Data Research UK websiteContactPress and PRThe University of EdinburghTel: +44 (0)7979 446 209Email: press.office@ed.ac.uk All other enquiriesProject manager: Dominique Balharry, University of Edinburghd.balharry@ed.ac.uk Scientific themesCOVID-19, Vaccine Pharmacovigilance, Pregnancy, Boosters, Variants
