This project is based at KEM HRC in India. Overview Project title: Weather variability, physiological responses and adaptation strategies among persons with Chronic Respiratory Diseases in Vadu Health and Demographic Surveillance SiteProgramme: Climate & HealthBased at: KEM Hospital Research Centre, IndiaStart date: 01 October 2024End date: Principal investigator: Dhiraj Agarwal Background Temperature variability is significantly associated with mortality and morbidity in the general population, with extreme heat and cold known to have significant effects on particular risk groups, including those with chronic respiratory diseases (CRD) such as asthma and chronic obstructive pulmonary disease. In India, the impact of heat on persons with CRD is poorly understood. Given that South Asia stands out as one of the hotspots for extreme heat events as the climate warms, such understanding is critical to inform the design of early warning systems and programs to protect people with CRD. While previous studies have observed reduction in physical activity in persons with CRD as the ambient temperature increases, it is unclear to what extent this reduction is simply a result of higher heat stress which occurs even in healthy individuals rather than due to the impact of CRD. Aim and Impact To provide better early warnings of extreme weather conditions for such at-risk groups, it is necessary to understand the additional physiological strain placed by weather variability on persons with CRD, and the behavioural adaptations (such as reduced physical activity) used to deal with extreme weather conditions. While laboratory measurements of physiological response have been conducted, this study seeks to conduct studies in real-life conditions. ObjectivesMeasure the relationship between heat stress and strain in persons with and without CRD. Record quantitative and qualitative metrics of heat strain and the corresponding changes in physical activity. Estimate the compounding effect of air quality on physical activity and heat-related strain. Use qualitative methods to assess behavioural adaptation strategies adopted by the subjects against extreme weather conditions. This article was published on 2025-11-19