Research from the first phase of RESPIRE (2016-2021) related to acute respiratory disorders. This programme of work focused on acute lower respiratory tract infections (such as pneumonia) as well as project launched in response to the coronavirus pandemic. Led by: Samir Saha, Child Health Research Foundation, and Harish Nair, University of Edinburgh RESPIRE projects in this area focus on four key areas The adaptation and tailoring of existing interventions, which can be incorporated into existing health care systems in each country. This also involves assessing the ability of such interventions to be delivered at a larger scale. To enrich and/or develop new cohorts of lower respiratory tract infections that will provide platforms for future clinical trials. Developing new interventions through small scale projects, to serve as proofs of concept for larger scale trials. Conducting multi-country trials to inform the development of new patient management guidelines, feeding into the evidence base for the World Health Organization (WHO). Completed projects Bubble CPAP for treatment of Bangladeshi children with severe pneumonia This project was based at icddr,b in Bangladesh Bubble CPAP for treatment of COVID-19 This project was based at icddr,b in Bangladesh Community perception on approaches to promote adherence to public health measures This project was based at Neoventive Solutions in Pakistan Computational framework to interpret chest X-rays and diagnose pneumonia This project was based at Child Health Research Foundation in Bangladesh Consequence of RSV infection in young infants This project was led from Bangladesh, also working with partners in India and Pakistan COVID-19 detection from chest X-rays using deep learning This project was based at Neoventive Solutions in Pakistan Development of ELISA and rapid testing kits for COVID-19 This project was based at Allergy and Asthma Institute, Pakistan Community use of digital auscultation in diagnosis of pneumonia This project was based at Projahnmo Research Foundation in Bangladesh Digital health in response to COVID-19 in low and middle income countries This project was based at the University of Malaya in Malaysia Hypertonic saline nasal irrigation and gargling for suspected COVID-19 This project was based at the Allergy and Asthma Institute, Pakistan Introducing pulse oximetry in IMCI services in Bangladesh This project was based at icddr,b in Bangladesh Introducing pulse oximetry in IMCI services in Pune district, India This project was based at King Edward Memorial (KEM) Hospital Research Centre, Pune in India Personal preparedness and self-protective measures of frontline health care workers This project was based at Fasiuddin Khan Research Foundation in Bangladesh Pneumonia case management practices in Pakistan This project was based at Neoventive Solutions in Pakistan Pneumonia related policy formation in Pakistan This project was based at Neoventive Solutions in Pakistan Fellows and PhD students In addition to the above projects, a number of our Fellows and PhD students are also working on stand-alone projects related to acute lower respiratory tract infections. Find out more about Nomana Zeeshan's Fellowship Find out more about Ahad Mahmud Khan's PhD studentship Find out more about Lois King's PhD studentship Find out more about Sudipto Roy's PhD studentship This article was published on 2024-09-24